Constitutive intestinal NF - k B does not trigger destructive inflammation unless accompanied by MAPK activation
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Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation
Nuclear factor (NF)-κB, activated by IκB kinase (IKK), is a key regulator of inflammation, innate immunity, and tissue integrity. NF-κB and one of its main activators and transcriptional targets, tumor necrosis factor (TNF), are up-regulated in many inflammatory diseases that are accompanied by tissue destruction. The etiology of many inflammatory diseases is poorly understood, but often depend...
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